An Efficient Green Synthesis of 3-Amino-1H-chromenes ...

2-amino-4H-chromenes,49,50 in this paper we introduce ZnO nanoparticles on a thin-film glass substrate by the mild hydro-thermal method and then used it for the first time as an efficient heterogeneous catalyst for the preparation of racemic 3-amino-1aryl-1H-benzo[f]chromene-2-carbonitriles (4) via a …

Journal of Heterocyclic Chemistry - Wiley Online Library

Journal of Heterocyclic Chemistry. ... These facts provide continued impetus to develop a wide range of methods for the synthesis of novel fused pyran and chromene derivatives ... Investigation of various conditions for a one-pot three-component reaction of 4-hydroxy-2H-benzo[h]chromene-2-one 1, benzaldehyde 2a, and malononitrile 3. Entry ...

US6686468B2 - H-annellated benzo[f]chromenes - Google Patents

The present invention relates to specific photochromic h-annellated benzo[f]chromene derivatives and their use in synthetic resins of all types, especially for ophthalmic applications. In particular, the present invention relates to photochromic compounds derived from benzo[f]chromenes, which in the open form have especially long-wave absorption maxima making it possible to obtain violet to ...

Pyridylmethylaminoacetic acid functionalized Fe magnetic ...

Abstract. 2-[(2-PyridylMethyl)Amino]Acetic acid (PMAA) functionalized Fe3O4 super-paramagnetic nanorods e ciently catalyzed three-component reaction of malononitrile, aromatic aldehydes, and phenolic or enolic components, such as -naphthol, -naphthol, dimedone, or kojic acid, to synthesize a variety of chromene or pyran derivatives in good

(IUCr) 3-Amino-1-(4-fluoro­phen­yl)-7-meth­­oxy-1H-benzo[f ...

In the title compound, C21H15FN2O2, the furan ring has a flattened half-chair conformation [the methine C atom lies 0.136 (2) Å above the C5 plane which has an r.m.s. deviation of 0.0229 Å]. Overall, the 1H-benzo[f]chromene fused-ring system approximates a plane (r.m.s. deviation of the 14 non-H atoms = 0.049 Å). The fluoro­benzene ring is almost perpendicular to this plane [dihedral angle ...

Crystal Structure of 2-amino-4-(4-hydroxyphenyl)-5, 10 ...

4H-benzo[g] chromene-3-carbonitrile D. K. Sharma1, A. Jayashree2, B. Narayana2, B. K. Sarojini3, ... methods and refined by full-matrix least squares procedures to a final R value of 0.1199 for 2629 observed ... (for C12 atom of the chromene ring system). The amino and cyanide groups attached at …

(PDF) List of publications for 2015 | Shaaban K Mohamed ...

Dr. Shaaban K. Mohamed List of Publications For 2015 A- Published articles: 1- Alaa A. Hassan, Shaaban.

Pd/C-catalyzed synthesis of 4-biaryl substituted 2-amino ...

Pd/C-catalyzed synthesis of 4-biaryl substituted 2-amino benzo[h] chromene derivatives as potential cytotoxic agents Article in Letters in Drug Design & Discovery 15(2):160-168 · February 2018 ...

Synthesis of Halogen Derivatives of Benzo[h]chromene and ...

Synthesis of Halogen Derivatives of Benzo[h]chromene and Benzo[a]anthracene with Promising Antimicrobial Activities. Article in Il Farmaco 57(9):715-22 · October 2002 with 39 Reads

An approach towards the oxidation of 2-amino-4H-chromenes ...

Dec 26, 2018· A novel method for the synthesis of 2-imino-2H-benzo[h]chromenes via the sequential addition of N-chlorosuccinimide and triethylamine to 2-amino-4H-benzo[h]chromenes has been established.This reaction protocol represents an efficient synthetic strategy to form iminochromene derivatives under mild reaction conditions, which utilizes readily accessible aminochromenes as …

Organic Chemistry International - Hindawi

On the other hand, heating a mixture of aromatic aldehydes (1a–h), malononitrile (2), and resorcinol (3) in boiling water containing a catalytic amount of Rochelle salt gave 2-amino-4-aryl-7-hydroxy-4H-chromene-3-carbonitriles 6a–h, in excellent yields.In contrast, neither α-naphthol nor β-naphthol underwent the above one-pot three-component reactions in boiling water even upon heating ...

Nano-sawdust–BF3 as a new, cheap, and effective nano ...

mild, and efficient method is still needed. In continuation of our previous research on the use of solid nano catalyst in organic synthesis [14–21], the nano-sawdust–BF 3 as a new catalyst has been applied for the synthesis of 2-amino benzo[h]chromene derivatives. Results and discussions In continuation of our investigation into the ...

"4-Aryl-4H-naphthopyrans Derivatives: One-Pot Synthesis ...

Methods: The one-pot, three-component reaction of a or beta-naphthol, malonitrile and an aromatic aldehyde in the presence of diammonium hydrogen phosphate was afforded the corresponding 2-amino-4-aryl-4H-benzo[h or f]chromene-3-carbonitrile derivatives, All target compounds were evaluated for inhibition of Src kinase and cell proliferation in ...

The One-step Synthesis of C,D-dihydropyrano[F] Chromene ...

This method has the advantages of a simple operation, mild reaction conditions, high yields, by using a less toxic and low cost chemical as a catalyst. Key words: One-step synthesis, Chromene, Environment friendly. In this paper we focus on the preparation of 3-amino-1-phenyl-1H-benzo[f]chromene-2-carbonitrile derivatives 4 (Scheme 1) in ...

New HA 14-1 analogues: synthesis of 2-amino-4-cyano-4H ...

Dec 01, 2010· The synthesis of 2-amino-4-cyano-4H-chromene derivatives as new HA 14-1 analogues by a simple and efficient method is reported.In addition, the reaction of 2-amino-2H-chromene-3-carbonitriles, salicylaldehydes and amines results in the formation of …

Crystal structure of 3-amino-1-(4-methoxyphenyl)-1H …

Crystal structure of 3-amino-1-(4-meth-oxyphenyl)-1H-benzo[f]chromene-2-carbonitrile Shaaban K. Mohamed,a,b Peter N. Horton,c Mehmet Akkurt,d Sabry H. H. Younese and Mustafa R. Albayatif* aChemistry and Environmental Division, Manchester Metropolitan University, Manchester M1 5GD, England, bChemistry Department, Faculty of Science, Minia University, 61519 El-Minia, Egypt, …

"4-Aryl-4 H -Naphthopyrans Derivatives: One-Pot Synthesis ...

Background: A series of 2-amino-4-aryl-4H-benzo[h or f]chromene-3-carbonitrile derivatives were synthesized and evaluated for inhibition of Src kinase and cell proliferation in breast carcinoma (BT-20) cell lines. Methods: The one-pot, three-component reaction of α or β-naphthol, malonitrile and an aromatic aldehyde in the presence of diammonium hydrogen phosphate was afforded the ...

1 FRONT PAGES - Shodhganga

related molecule such as 2-amino-3-cyano-6-hydroxy-4-phenyl-4H- benzo[f]chromene [29] is compared with that of the title compound. Most of the optimized bond lengths and bond angles are slightly greater than the experimental values for both HF and DFT levels, due to the fact that the theoretical calculations

Convenient and Efficient One-Pot Method for the Synthesis ...

Abstract A convenient and efficient one-pot method for the synthesis of 2-amino-tetrahydro-4H-chromene and 2-amino-4H-benzo[h]-chromene derivatives has been developed using a catalytic amount of amino-functionalized MCM-41 in aqueous medium. This efficient technique has the advantages of giving 4H-tetrahydro-chromene and 4H-benzo[h]chromene building blocks using a …

2 amino benzo f chromene grinding method - pureaquaworld.co.in

2 Amino Benzo F Chromene Grinding Method. Cellulose sulfuric acid an efficient biopolymer-based isomers of some 1 3-diaryl-H-benzo f chromene have been and indirect methods in solvent media and grinding method in a solvent-free media were

The One-Step Synthesis of 3,4-Dihydropyrano[F]Chromene ...

Table 1: 3-amino-1-phenyl-1H-benzo[f]chromene-2-carbonitrile 4a–g in under grinding using DABCO Yields refer to pure isolated products characterized b y IR, 1 H and 13 C N MR spectroscopy and mass spectrometry. The structures of compounds 4 were deduced from their 1 H NMR, 13 C NMR and IR spectral data and their molecular weight confirmed by mass spectrometry.

Synthesis of ethyl-3-amino-1-aryl-1H-benzo[f]chromeme-2 ...

new method for the synthesis of chromene derivatives using DMAP as catalyst and co-solvent (additive), as a rapid convenient method with suitable yields. The point is which lead to higher purity ... Ethyl 3-amino-1-p-tolyl-1H-benzo[f]chromene-2-carboxylate (5f).

Synthesis of 2-aminochromene derivatives catalyzed by KF ...

Request PDF on ResearchGate | Synthesis of 2-aminochromene derivatives catalyzed by KF/Al 2O3 | A series of 2-aminochromene derivatives including 2-amino-benzo [h] chromene, 2-amino-benzo [f ...

Grindstone Chemistry: An Efficient and Green Synthesis of ...

A single step, mild, environmentally friendly green method has been developed for the synthesis of physiologically active 2-amino-4H-benzo[b]pyrans employing solid sodium ethoxide as catalyst under solvent free conditions at room temperature via grinding. The procedure is efficient, time saving and gives high yield. The structures and purity of ...

Convenient Synthesis of 2-Amino-4H-chromenes from ...

2-Amino-4H-chromene constituents are widely found in natural products, and their biological activities have attracted much attention in medicinal chemistry .Of their synthetic methods, the reaction of phenols (naphthols) with benzylidenemalononitriles or three-component reaction of the phenols, aldehydes, and malononitrile via intermediate A has been used most frequently using various ...

Synt hesis, antitumor activity of 2-amino-4 H-benzo[ h]c ...

Abstract. Several 2-amino-4H-benzo[h]chromenes (3a–i) and (5a–h) were obtained by reaction of 4-chloro-1-naphthol (1) with α-cyanocinnamonitrile (2a–i) or ethyl α-cyanocinnamate derivatives (4a–h), respectively.Structures of these compounds were established on the basis of spectral data. The antitumor activity of the synthesized compounds was investigated in comparison with ...

Synthesis of ethyl-3-amino-1-aryl-1H-benzo[f]chromeme-2 ...

In simple reaction conditions, the use of DMAP is explored as an easy workup and a green catalyst for the one-pot three-component synthesis ethyl 3-amino-1-aryl-1H-benzo[f]chromene-2-carboxylate derivatives. How to cite this paper

Multicomponent assembling of salicylaldehydes ...

A new multicomponent reaction (MCR) was found: a sodium acetate-catalyzed transformation of salicylaldehydes, malononitrile and 4-hydroxy-6-methyl-2H-pyran-2-one in ethanol results in the fast (30 min) and efficient formation of new 4-pyrano-substituted 2-amino-4H-chromenes in 86–96% yields.The same transformation initiated by grinding in mortar in the presence of sodium acetate or potassium ...